Repository of Research and Investigative Information

Repository of Research and Investigative Information

Larestan University of Medical Sciences

Evaluation of potential anti-fibrotic effect of oleuropein on bleomycin-induced pulmonary fibrosis in rat

(2018) Evaluation of potential anti-fibrotic effect of oleuropein on bleomycin-induced pulmonary fibrosis in rat. Toxin Reviews. ISSN 15569543 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

The etiology of idiopathic pulmonary fibrosis (IPF) is not well known, however it is a final response of frequent injuries to endothelial and epithelial cells that cause influx of the inflammatory cells. Bleomycin (BLM), a chemotherapeutic agent that causes lung fibrosis in human patients has been applied extensively in rodent models to inducing IPF. Moreover, oxidative stress and production of reactive oxygen species (ROS) have been involved in the pathogenesis. We aimed to investigate the effect of main olive antioxidant and anti-inflammatory polyphenol constituent, oleuropein (OLE), on BLM-induced fibrosis model. Female Wistar rats were divided into six groups (n = 8). In this study, whereas negative group only received vehicle and treatment groups received OLE (20, 40, and 80 mg kg−1) orally. Also, positive control group received intratracheally (IT), single dose BLM (7.5 U kg−1), prednisolone (10 mg/kg) as standard cure a week before and 3 weeks after IT-BLM. At 21th day of experiment, IL-13, TNF, TGF-β, and PDGF in the bronchoalveolar fluid (BALF), lung content hydroxyproline (HP), and malondialdehyde (MDA) were quantified. Histopathological changes in lungs were investigated too. IL-13, TNF, TGF-β1, PDGF in BALF, lung HP (collagen index), and MDA content in BLM-injected group was significantly higher than the control group (p <.05). In contrast, rats treated with OLE showed obviously lesser contents. Also, the histopathological observation confirms these findings. The results indicate that treatment by OLE may inhibit production of anti-inflammatory cytokines and ROS, and thus could be a useful medicine for managing fingagin disorders. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Keywords: Bleomycin oleuropein pulmonary fibrosis rat reactive oxygen species
Divisions: Education Vice-Chancellor Department > Faculty of Nursing and Midwifery > Department of Nursing
Journal or Publication Title: Toxin Reviews
Journal Index: Scopus
Identification Number: https://doi.org/10.1080/15569543.2018.1488733
ISSN: 15569543 (ISSN)
Depositing User: خانم موهبت شیوخی
URI: http://eprints.larums.ac.ir/id/eprint/122

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