Repository of Research and Investigative Information

Repository of Research and Investigative Information

Larestan University of Medical Sciences

Metabolic Syndrome Patients Have Lower Levels of Adropin When Compared With Healthy Overweight/Obese and Lean Subjects

(2017) Metabolic Syndrome Patients Have Lower Levels of Adropin When Compared With Healthy Overweight/Obese and Lean Subjects. American Journal of Men's Health. pp. 426-434. ISSN 15579883 (ISSN)

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Metabolic syndrome (MetS), a cluster of cardiometabolic risk factors, is a challenging public health issue. The aim of current study was to test the hypothesis that concentrations of plasma adropin and leptin differ between patients with MetS and comparable age- and sex-matched control groups. This case-control study involved 153 subjects (51 per group). The study group included obese subjects with MetS and the two control groups included weight-matched subjects without MetS (“healthy”: obese) and normal weight subjects without MetS. Body composition parameters were measured using bioelectrical impedance analysis. Plasma levels of adropin, leptin, and their ratio were measured. Leptin was significantly different between obese patients with/without MetS groups and normal weight subjects. Patients with MetS had higher levels of leptin (14 ± 12.4) compared with those without MetS (11.2 ± 9.3 vs. 7 ± 7.1 obese and normal weight without MetS, respectively; p =.002). Compared with healthy obese and normal weight subjects, MetS subjects had lower levels of plasma adropin (p <.001) and a lower plasma adropin to leptin ratio (p <.001), which remained significant when adjusted for body fat mass by analysis of covariance (p <.001). This study demonstrates low levels of adropin are correlated with MetS and hence identify it as a potentially protective agent against MetS development. Variation in adropin levels may partly explain the “healthy obese” phenomenon. © 2016, © The Author(s) 2016.

Item Type: Article
Keywords: adropin body composition leptin metabolic syndrome obesity adiponectin biological marker Enho protein, human peptide plasma protein adult anthropometry blood body mass case control study comparative study human male metabolic syndrome X middle aged risk factor Biomarkers Blood Proteins Body Mass Index Case-Control Studies Humans Peptides Risk Factors
Divisions: Education Vice-Chancellor Department > Faculty of Health > Department of Public health
Page Range: pp. 426-434
Journal or Publication Title: American Journal of Men's Health
Journal Index: Scopus
Volume: 11
Number: 2
Identification Number:
ISSN: 15579883 (ISSN)
Depositing User: خانم موهبت شیوخی

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