Repository of Research and Investigative Information

Repository of Research and Investigative Information

Larestan University of Medical Sciences

The status of Hepatitis G/C Virus among HIV positive patients and effects of GBV-C on the progress of HIV infection

(2016) The status of Hepatitis G/C Virus among HIV positive patients and effects of GBV-C on the progress of HIV infection. Research Journal of Medical Sciences. pp. 91-96. ISSN 18159346 (ISSN)

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Abstract

Individuals infected with the Human Immunodeficiency Virus (HIV) are often co-infected with other pathogens in particular hepatitis viruses. HCV and GBV-C are blood-borne viruses that are highly prevalent among HIV/AIDS patients. The aim of this study was to evaluate the presence of hepatitis G virus (GBV-C) among HIV positive patients and its effect on the progress of HIV disease. One hundred and fifty HIV infected patients (92 men and 58 women) were included in this study. Patients were categorized into four different high-risk groups: intravenous drug users (n = 48), hemophiliacs (n = 45), homosexuals (n = 32) and heterosexuals (n = 25). RNA was extracted from 100 µL of serum or plasma using RNX plus kit. Reverse Transcription Polymerase Chain Reaction (RT-PCR) and nested PCR were used to detect GBV-C-RNA and HCV-RNA. GBV-C-RNA and HCV-RNA were found in 26.66 and 30 of patients, respectively. The prevalence of GBV-C for intravenous drug users, hemophiliacs, homosexuals, heterosexuals those with history of kidney disease and patients with a history of liver disease was 31.25, 28.88, 21.88, 20, 28.58 and 25, respectively. Data show that within 4 years, CD+4 cell counts increased from 398-502 cells/mm3 while HIV-RNA load decreased to 2.1±0.7 log10copies/mL and HGV-RNA load increased to 2.5±2.08 log10 copies/mL. The prevalence of GBV-C and HCV in HIV infection variy in different groups. Our study shows a significant relationship between co-infection with GBV-C and HIV since it slows the progression of HIV and liver diseases in 4 years after being infected. © Medwell Journals, 2016.

Item Type: Article
Keywords: Cell counts GBV-C HCV Human immunodeficiency virus (HIV) RT-PCR adult Article CD4 lymphocyte count controlled study enzyme linked immunosorbent assay female hepatitis C hepatitis G Hepatitis G virus homosexuality human Human immunodeficiency virus infection major clinical study male mixed infection reverse transcription polymerase chain reaction RNA isolation virus load
Divisions: Education Vice-Chancellor Department > Faculty of Health > Department of Environmental Health Engineering
Page Range: pp. 91-96
Journal or Publication Title: Research Journal of Medical Sciences
Journal Index: Scopus
Volume: 10
Number: 3
Identification Number: https://doi.org/10.3923/rjmsci.2016.91.96
ISSN: 18159346 (ISSN)
Depositing User: خانم موهبت شیوخی
URI: http://eprints.larums.ac.ir/id/eprint/158

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