Repository of Research and Investigative Information

Repository of Research and Investigative Information

Larestan University of Medical Sciences

The role of microRNAs regulating the expression of matrix metalloproteinases (MMPs) in breast cancer development, progression, and metastasis

(2019) The role of microRNAs regulating the expression of matrix metalloproteinases (MMPs) in breast cancer development, progression, and metastasis. Journal of Cellular Physiology. pp. 5399-5412. ISSN 0021-9541

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Abstract

MicroRNAs (miRNAs) regulate several biological and physiological processes in mammalian cells, including cellular proliferation, differentiation, apoptosis, and metabolism. Recent studies have confirmed the alteration of them during the cancer development. Matrix metalloproteinases (MMPs), belonging to the large family of proteases, have also been demonstrated to play crucial roles in tissue remodeling, and to support cancer progression and metastasis. There are several known miRNAs which regulate the MMP family and their expression. The expression profiles of miRNAs involved in MMP regulation, change during cancer progression, and metastasis. The present review focuses on important miRNAs capable of targeting MMPs through direct and indirect interactions during the breast cancer development, progression, and metastasis.

Item Type: Article
Keywords: breast cancer matrix metalloproteinases metastasis microRNA progression epithelial-mesenchymal transition cell invasion tumor-suppressor growth-factor therapeutic application promotes proliferation collagenase-3 mmp-13 metallopeptidase 13 prognostic markers tissue inhibitor Cell Biology Physiology
Divisions: Education Vice-Chancellor Department > Faculty of Nursing and Midwifery > Department of Nursing
Page Range: pp. 5399-5412
Journal or Publication Title: Journal of Cellular Physiology
Journal Index: ISI
Volume: 234
Number: 5
Identification Number: https://doi.org/10.1002/jcp.27445
ISSN: 0021-9541
Depositing User: خانم موهبت شیوخی
URI: http://eprints.larums.ac.ir/id/eprint/175

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