Repository of Research and Investigative Information

Repository of Research and Investigative Information

Larestan University of Medical Sciences

Adiponectin: An Indicator for Metabolic Syndrome

(2019) Adiponectin: An Indicator for Metabolic Syndrome. Iranian Journal of Public Health. pp. 1106-1115. ISSN 2251-6085

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Background: Metabolic syndrome (MetS), a cluster of cardiometabolic risk factors, consider as a manifestation of obesity. However, a proportion of obese patients do not develop MetS. The aim of our study was to determine whether concentration of plasma adiponectin and leptin differ between metabolic unhealthy obese (MUO) patients and comparable age- and sex-matched control groups. Methods: In this case-control study, we assigned 51 obese patients with MetS (MUO) in cases group and 102 metabolic healthy obese (MHO) and normal weight metabolic healthy subjects matched for age and gender to cases in control groups. The study was conducted between December 2014 and February 2016 in the Endocrinology Research Center of Tehran University of Medical Sciences , Tehran , Iran. We measured serum adiponectin, leptin, their ratio, and body composition in all subjects. Results: No significant differences were observed between MHO and MUO in term of total fat mass and trunk fat (P>0.05). Compared to MHO and normal weight metabolic healthy subjects, MUO subjects had lower levels of plasma adiponectin (P<0.001) and lower plasma adiponectin to leptin ratio (P<0.001) and a higher level of plasma leptin (P<0.002). A Receiver Operator Characteristic curve was used to identify the ability of adiponectin and leptin level to predict the MetS. The area under the Receiver Operator Characteristic curve was 0.66 (P<0.01), 0.73 (P<0.001) and 0.75 (P<0.001) for leptin, adiponectin, and adiponectin/leptin ratio levels respectively. Conclusion: Our study introduced adiponectin and leptin as indicator of MetS and obesity respectively.

Item Type: Article
Keywords: Leptin; Adiponectin; Metabolic syndrome; Fat mass
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Nutrition
Page Range: pp. 1106-1115
Journal or Publication Title: Iranian Journal of Public Health
Journal Index: ISI
Volume: 48
Number: 6
ISSN: 2251-6085
Depositing User: خانم موهبت شیوخی

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