Repository of Research and Investigative Information

Repository of Research and Investigative Information

Larestan University of Medical Sciences

Bordetella pertussis antigens encapsulated into N-trimethyl chitosan nanoparticuiate systems as a novel intranasal pertussis vaccine

(2019) Bordetella pertussis antigens encapsulated into N-trimethyl chitosan nanoparticuiate systems as a novel intranasal pertussis vaccine. Artificial Cells Nanomedicine and Biotechnology. pp. 2605-2611. ISSN 2169-1401

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Abstract

The mucosal immune system serves as the first line of defense against Bordetella pertussis. Intranasal vaccination, due to its potential to induce systemic and mucosal immune responses, appears to prevent the initial adherence and colonization of the bacteria at the first point of contact. In the present study, two B. pertussis antigens, pertussis Toxoid (PTd) and Filamentous hemagglutinin (FHA), which play a very significant role in virulence and protection against pertussis, were encapsulate into N-trimethyl chitosan (TMC) nanoparticulate systems. After preparation of TMC nanoparticles (NPs), the NPs were characterized and their ability to induce efficient immune responses against B. pertussis was studied in a mouse model. Our findings showed that PTd + FHA-loaded TMC NPs have strong ability to induce IL-4, IL-17, IFN-gamma, IgG, and IgA in the mouse model. Results from this study suggest that nasal administration of the PTd + FHA-loaded TMC NPs induced not only a systemic immune response but also a local mucosal response, which may improve the efficacy of pertussis prevention through respiratory tract transmission.

Item Type: Article
Keywords: N-Trimethyl chitosan (TMC); Bordetella pertussis; intranasal immunization; nanoparticle vaccine
Divisions: Education Vice-Chancellor Department > Faculty of Nursing and Midwifery > Department of Nursing
Page Range: pp. 2605-2611
Journal or Publication Title: Artificial Cells Nanomedicine and Biotechnology
Journal Index: ISI
Volume: 47
Number: 1
Identification Number: https://doi.org/10.1080/21691401.2019.1629948
ISSN: 2169-1401
Depositing User: خانم موهبت شیوخی
URI: http://eprints.larums.ac.ir/id/eprint/185

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