Repository of Research and Investigative Information

Repository of Research and Investigative Information

Larestan University of Medical Sciences

Emerging roles of exosomal miRNAs in breast cancer drug resistance

(2019) Emerging roles of exosomal miRNAs in breast cancer drug resistance. Iubmb Life. ISSN 1521-6543

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Abstract

Breast cancer (BC), as a heterogeneous disease, is considered as one of the most common malignancies in women worldwide. The resistance of BC cells to therapeutic agents has remained a big challenge in the treatment of BC patients. Some factors such as cytokines, exosomes, and soluble receptors were recognized as crucial agents involved in the development of drug resistance. However, the exact mechanisms underlying the drug resistance is still unknown. There is growing evidence to support the emerging roles of exosomes, especially exosomal miRNAs, in tumor initiation, angiogenesis, proliferation, migration, invasion, metastasis, and drug resistance. Therefore, identification of BC-specific exosomal miRNAs and their underlying mechanisms would be helpful to define sensitivity to therapeutic drugs and establish an appropriate therapeutic strategy. This review focuses mainly on the roles of exosomal miRNAs and their associated mechanisms in the resistance of BC cells to therapeutic agents, as well as critically examines the potential of these macromolecules as a treatment biomarker in BC patients.

Item Type: Article
Keywords: breast cancer exosomes drug resistance therapeutics exosomal miRNA microRNA
Divisions: Education Vice-Chancellor Department > Faculty of Nursing and Midwifery > Department of Nursing
Journal or Publication Title: Iubmb Life
Journal Index: ISI
Identification Number: https://doi.org/10.1002/iub.2116
ISSN: 1521-6543
Depositing User: خانم موهبت شیوخی
URI: http://eprints.larums.ac.ir/id/eprint/186

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