Repository of Research and Investigative Information

Repository of Research and Investigative Information

Larestan University of Medical Sciences

Adeno-associated virus as a gene therapy vector: strategies to neutralize the neutralizing antibodies

(2019) Adeno-associated virus as a gene therapy vector: strategies to neutralize the neutralizing antibodies. Clinical and Experimental Medicine. pp. 289-298. ISSN 1591-8890

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Abstract

Adeno-associated virus (AAV)-derived vectors are currently the most common type of viral vectors used in gene therapy clinical trials. The presence of neutralizing antibodies (NAbs) against wild-type AAVs in the host body is one of the limitations for the successful use of AAV vectors. AAV capsid manipulation, by which recombinant vectors lose their ability to interact with NAbs, can help overcome this obstacle. Various methods can be used for this purpose, including directed evolution as well as conjugation of certain chemical groups to AAV epitopes. The present review concisely explains the use of AAV vectors in the clinic for gene therapy of some diseases, their limitations, and solutions to these limitations.

Item Type: Article
Keywords: Gene therapy Adeno-associated vectors Neutralizing antibodies Capsid modification
Divisions: Education Vice-Chancellor Department > Faculty of Nursing and Midwifery > Department of Nursing
Page Range: pp. 289-298
Journal or Publication Title: Clinical and Experimental Medicine
Journal Index: ISI
Volume: 19
Number: 3
Identification Number: https://doi.org/10.1007/s10238-019-00557-8
ISSN: 1591-8890
Depositing User: خانم موهبت شیوخی
URI: http://eprints.larums.ac.ir/id/eprint/189

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