Repository of Research and Investigative Information

Repository of Research and Investigative Information

Larestan University of Medical Sciences

Immunologic balance of regulatory T cell/T helper 17 responses in gastrointestinal infectious diseases: Role of miRNAs

(2019) Immunologic balance of regulatory T cell/T helper 17 responses in gastrointestinal infectious diseases: Role of miRNAs. Microbial Pathogenesis. pp. 135-143. ISSN 08824010 (ISSN)

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Gastrointestinal Infectious diseases (GIDs) are the second cause of death worldwide. T helper17 cells (Th17) play an important role in GIDs through production of IL-17A, IL-17F, and IL-22 cytokines. Because of their increased activities in GID, Th17 and its inflammatory cytokines can inhibit the progression and eliminate the infection. Actually, although Th17 have the best performance in the acute phase, regulatory T cells (Treg cells) are enhanced in the chronic phase and infection progress through its suppressive function. In addition, Treg cells prevent undesirable inflammatory damages developed by immune system components. On the other hand, miRNAs have important roles in the regulation of immune responses to eliminate bacterial infections and protect host organisms from harmful effects. Actually, miRNAs can reinforce innate and adaptive immunity to remove infections. Of note, miRNAs can develop a regulatory network with the immune system. Additionally, miRNAs can also serve in favor of bacteria to reduce immune responses. Therefore, balance of immune responses in Treg and Th17 cells can influence outcome of many infectious diseases. In conclusion, there is an imbalance in the Treg/Th17 ratio in GIDs; importantly, sets of miRNAs, particularly miR155 and miR146, were determined to be involved clearly in GIDs. © 2019 Elsevier Ltd

Item Type: Article
Keywords: Gastrointestinal diseases Immunologic balance miRNAs Th17 Treg microRNA microRNA 146 microRNA 155 unclassified drug cytokine IL17A protein, human IL17F protein, human interleukin 17 MIRN146 microRNA, human adaptive immunity bacterial infection bacterial virulence cell function cellular immunity clinical outcome gastrointestinal infection gene function gene interaction host bacterium interaction human immune response immune system innate immunity nonhuman priority journal regulatory T lymphocyte Review Th17 cell disease exacerbation gastrointestinal disease immunity immunology metabolism microbiology physiology Cytokines Disease Progression Interleukin-17 MicroRNAs T-Lymphocytes, Regulatory Th17 Cells
Divisions: Education Vice-Chancellor Department > Faculty of Nursing and Midwifery > Department of Nursing
Page Range: pp. 135-143
Journal or Publication Title: Microbial Pathogenesis
Journal Index: Scopus
Volume: 131
Identification Number:
ISSN: 08824010 (ISSN)
Depositing User: خانم موهبت شیوخی

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