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Repository of Research and Investigative Information

Larestan University of Medical Sciences

Comparing serum concentration of spexin among patients with metabolic syndrome, healthy overweight/obese, and normal-weight individuals

(2019) Comparing serum concentration of spexin among patients with metabolic syndrome, healthy overweight/obese, and normal-weight individuals. Medical Journal of the Islamic Republic of Iran. ISSN 10161430 (ISSN)

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Abstract

Background: There are many factors related to etiology of metabolic syndrome (MetS) including obesity. Spexin, a peptide hormone released from adipose tissue, is the most down-regulated gene in obese, compared to non-obese adipose tissue. Hence, it potentially contributes to the progression and development of metabolic diseases. This study was designed to evaluate serum concentration of spexin in patients with MetS compared to weight-matched and normal-weight controls. Methods: In this case-control study, 153 participants (51 per group) were collected from October 2014 to June 2016. The study groups were all matched for age and sex and included overweight/obese individuals with MetS and 2 control groups without MetS (including weight-matched and normal-weight participants). Body composition and serum concentration of spexin and leptin were measured. Results: Serum leptin and spexin levels were significantly higher and lower, respectively, in normal-weight compared to overweight/obese groups with/without MetS (p < 0.02). No significant difference was observed in serum leptin and spexin concentrations between the overweight/obese groups with/without MetS (p ≥ 0.05). Also, spexin, with cutoff value of 4.6, had 78 sensitivity and 82 specificity for diagnosing overweight/obese from normal-weight participants. Spexin had 78 sensitivity and specificity, with cutoff value of 4.35, in diagnosing MetS participants from normal-weight group. Conclusion: This study found no correlation between the circulating level of spexin and MetS development. Higher serum concentration of spexin in normal-weight adults compared to the obese participants illustrated the potential role of this novel peptide in obesity. © Iran University of Medical Sciences.

Item Type: Article
Keywords: Leptin Metabolic syndrome Obesity Spexin
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Nutrition
Journal or Publication Title: Medical Journal of the Islamic Republic of Iran
Journal Index: Scopus
Volume: 33
Number: 1
Identification Number: https://doi.org/10.34171/mjiri.33.93
ISSN: 10161430 (ISSN)
Depositing User: خانم موهبت شیوخی
URI: http://eprints.larums.ac.ir/id/eprint/203

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