Repository of Research and Investigative Information

Repository of Research and Investigative Information

Larestan University of Medical Sciences

Toxic effects of subacute inhalation exposure to trichloroethylene on serum lipid profile, glucose and biochemical parameters in Sprague-Dawley rats

(2018) Toxic effects of subacute inhalation exposure to trichloroethylene on serum lipid profile, glucose and biochemical parameters in Sprague-Dawley rats. Inhalation Toxicology. pp. 354-360. ISSN 0895-8378

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Abstract

The current study evaluated the inhalation toxicity of trichloroethylene (TCE) at 0, 10, 100, 250 and 400ppm in Sprague-Dawley rats for 10 day period, because the subacute inhalation toxicity of TCE on serum lipid profile, glucose and some biochemical parameters has not been previously reported. TCE vapors were generated using the dynamic generation system based on evaporation method in the exposure chamber. On the basis of the results, mean serum low-density lipoprotein (LDL) and albumin (ALB) decreased significantly in all the groups exposed to TCE compared with the control group (p<.005), but there was a significant increase for parameters: fasting blood glucose (FBG) and alkaline phosphatase (ALP) (p<.005). Rats exposed to 400ppm TCE showed a significant decrease in serum cholesterol (CHOL) and protein (Pr) compared with the control group (p<.005). A negative relationship was found between triglycerides (TG), very low density lipoprotein (VLDL), CHOL, LDL, Pr, ALB and urea levels and the subacute exposure to concentrations of TCE (R-2=-0.26, p<.05), but there was a direct correlation for parameters FBG, ALP and alanine aminotransferase (ALT) (R-2=0.42, p<.05). In conclusion, studies with Sprague-Dawley rats demonstrated that subacute inhalation exposure to TCE ( 100PPM) is associated with biochemical and lipotoxicity in the form of decreased serum ALB and LDL and raised ALP and glucose levels. The present study also provides additional evidence relating to decreased serum CHOL and Pr after subacute inhalation exposure to 400ppm TCE.

Item Type: Article
Keywords: Trichloroethylene lipid profile glucose biochemical parameter subacute exposure animal model mediated autoimmunity protein adducts liver metabolism activation contribute receptor Toxicology
Divisions: Education Vice-Chancellor Department > Faculty of Health > Department of Environmental Health Engineering
Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Nutrition
Page Range: pp. 354-360
Journal or Publication Title: Inhalation Toxicology
Journal Index: ISI
Volume: 30
Number: 9-10
Identification Number: https://doi.org/10.1080/08958378.2018.1526233
ISSN: 0895-8378
Depositing User: خانم موهبت شیوخی
URI: http://eprints.larums.ac.ir/id/eprint/220

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