Repository of Research and Investigative Information

Repository of Research and Investigative Information

Larestan University of Medical Sciences

How hypoxia regulate exosomes in ischemic diseases and cancer microenvironment?

(2019) How hypoxia regulate exosomes in ischemic diseases and cancer microenvironment? Iubmb Life. p. 20. ISSN 1521-6543

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Abstract

Exosomes, as natural occurring vesicles, play highly important roles in the behavior and fate of ischemic diseases and different tumors. Secretion, composition, and function of exosomes are remarkably influenced by hypoxia in ischemic diseases and tumor microenvironment. Exosomes secreted from hypoxic cells affect development, growth, angiogenesis, and progression in ischemic diseases and tumors through a variety of signaling pathways. In this review article, we discuss how hypoxia affects the quantity and quality of exosomes, and review the mechanisms by which hypoxic cell-derived exosomes regulate ischemic cell behaviors in both cancerous and noncancerous cells.

Item Type: Article
Keywords: exosomes HIF-alpha hypoxia ischemic diseases metastasis microvesicles tumor microenvironment intercellular-communication tumor-growth cells microvesicles angiogenesis vesicles accumulation invasiveness macrophages metastasis Biochemistry & Molecular Biology Cell Biology
Divisions: Education Vice-Chancellor Department > Faculty of Nursing and Midwifery > Department of Nursing
Page Range: p. 20
Journal or Publication Title: Iubmb Life
Journal Index: ISI
Identification Number: https://doi.org/10.1002/iub.2275
ISSN: 1521-6543
Depositing User: خانم موهبت شیوخی
URI: http://eprints.larums.ac.ir/id/eprint/244

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