Repository of Research and Investigative Information

Repository of Research and Investigative Information

Larestan University of Medical Sciences

Targeting STAT3 in cancer and autoimmune diseases

(2020) Targeting STAT3 in cancer and autoimmune diseases. European Journal of Pharmacology. ISSN 0014-2999

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Abstract

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated downstream of a broad range of receptors particularly interleukin-6 (IL-6) family. STAT3 is the key regulator of cell proliferation, survival and apoptosis and is constitutively activated in most human cancers, indicating that it can be an important potential therapeutic target for cancer treatment. STAT3 also has important roles in lymphocyte biology, regulation of immune responses and autoimmunity. Considering the vital role of STAT3 in tumor progression and autoimmunity, scientists have focused to develop small molecules that suppress STAT3 function. In this review, we firstly discussed the predominant role of STAT3 in cancer and autoimmune diseases. Subsequently, we discussed the efficacy and therapeutic potential of different STAT3 inhibitors in cancer and autoimmune diseases in preclinical studies and clinical trials offering an insight into novel approaches for development of new STAT3 inhibitors.

Item Type: Article
Keywords: STAT3; Cancer; Autoimmune diseases; Small molecule inhibitors
Divisions: Education Vice-Chancellor Department > Faculty of Nursing and Midwifery > Department of Nursing
Journal or Publication Title: European Journal of Pharmacology
Journal Index: ISI
Volume: 878
Identification Number: https://doi.org/10.1016/j.ejphar.2020.173107
ISSN: 0014-2999
Depositing User: خانم موهبت شیوخی
URI: http://eprints.larums.ac.ir/id/eprint/265

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