Repository of Research and Investigative Information

Repository of Research and Investigative Information

Larestan University of Medical Sciences

The role of Human leukocyte antigen class I on patient survival in Gastrointestinal cancers: a systematic review and meta- analysis

(2020) The role of Human leukocyte antigen class I on patient survival in Gastrointestinal cancers: a systematic review and meta- analysis. Scientific Reports. ISSN 2045-2322

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Abstract

The prognostic role of Human leukocyte antigen class I (HLA- I) in gastrointestinal cancers has been remained controversial. We performed a meta-analysis to determine the role of classical HLA-I in predicting survival of patients. In addition, the relationship between HLA- I and some clinicopathological factors was evaluated. Published studies investigated HLA-I expression effect on gastrointestinal cancers were evaluated to determine association between HLA- I and overall survival (OS) and recurrence-free survival (RFS) in patients. The used effect sizes were hazard ratio (HR) and Odds ratio (OR) with 95 confidence interval (CI). A total of ten studies included 1307 patients were analyzed. The pooled results revealed that HLA- I overexpression was positively related to OS (HR: 0.72; 95 CI: 0.53-0.96) and demonstrated little association for RFS (HR: 0.70; 95 CI: 0.46-1.08). HLA-I overexpression is negative associated with poorer differentiation of tumor (OR: 0.53; 95 CI (0.43-0.81) and also higher stages of cancer (OR: 0.29; 95 CI (0.13-0.64). HLA- I overexpression was related to a better prognosis on OS and probably had little impact on RFS.

Item Type: Article
Keywords: HLA CLASS-I; SQUAMOUS-CELL CARCINOMA; MHC CLASS-I; DOWN-REGULATION; PROGNOSTIC-FACTORS; COLORECTAL-CANCER; POOR-PROGNOSIS; PUBLICATION BIAS; LIGAND 1; EXPRESSION
Divisions: Education Vice-Chancellor Department > Faculty of Nursing and Midwifery > Department of Nursing
Journal or Publication Title: Scientific Reports
Journal Index: ISI
Volume: 10
Number: 1
Identification Number: https://doi.org/10.1038/s41598-020-57582-x
ISSN: 2045-2322
Depositing User: خانم موهبت شیوخی
URI: http://eprints.larums.ac.ir/id/eprint/279

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