Repository of Research and Investigative Information

Repository of Research and Investigative Information

Larestan University of Medical Sciences

An overview of the innate and adaptive immune system in atherosclerosis

(2020) An overview of the innate and adaptive immune system in atherosclerosis. Iubmb Life. p. 28. ISSN 1521-6543

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Abstract

Cardiovascular disease is the leading cause of death globally. Coronary artery disease (CAD) is a chronic inflammatory disease usually caused by atherosclerosis, in which the coronary arteries become narrowed by atheromatous plaque. Plaques in atherosclerosis are formed through the accumulation of lipids and various immune cells. Both adaptive and innate immune systems are involved in the pathogenesis of atherosclerosis and facilitate plaque formation and disease progression. Almost all immune system cells, including neutrophils, B cells, T cells monocytes, macrophages, foam cells, and dendritic cells (DCs), play a vital role in atherosclerotic plaque. Atherogenesis, the normal function of the endothelium, is initially disrupted and, then, cells of the immune system are recruited to the endothelium following increased expression of cell adhesion molecules. Accumulation of immune cells and lipids leads to the formation of a necrotic nucleus. As the disease progresses, smooth muscle cells form fibrous layers, whose rupture results in exposing the necrotic nucleus and thrombosis. Accordingly, the present review was conducted to determine the role of different cells in innate and adaptive immune systems in inhibition and progression of atherosclerosis.

Item Type: Article
Keywords: adaptive immune systems atherosclerosis innate immune system low-density-lipoprotein regulatory t-cells acute coronary syndrome toll-like receptors acute myocardial-infarction apolipoprotein e-deficient c-reactive protein dendritic cells oxidized ldl mast-cells Biochemistry & Molecular Biology Cell Biology
Divisions: Education Vice-Chancellor Department > Faculty of Nursing and Midwifery > Department of Nursing
Page Range: p. 28
Journal or Publication Title: Iubmb Life
Journal Index: ISI
Identification Number: https://doi.org/10.1002/iub.2425
ISSN: 1521-6543
Depositing User: خانم موهبت شیوخی
URI: http://eprints.larums.ac.ir/id/eprint/304

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