Repository of Research and Investigative Information

Repository of Research and Investigative Information

Larestan University of Medical Sciences

Chimeric Antigen Receptor Based Therapy as a Potential Approach in Autoimmune Diseases: How Close Are We to the Treatment?

(2020) Chimeric Antigen Receptor Based Therapy as a Potential Approach in Autoimmune Diseases: How Close Are We to the Treatment? Frontiers in Immunology. p. 12. ISSN 1664-3224

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Abstract

Despite significant breakthroughs in understanding of immunological and physiological features of autoimmune diseases, there is currently no specific therapeutic option with prolonged remission. Cell-based therapy using engineered-T cells has attracted tremendous attention as a practical treatment for autoimmune diseases. Genetically modified-T cells armed with chimeric antigen receptors (CARs) attack autoreactive immune cells such as B cells or antibody-secreting plasma cells. CARs can further guide the effector and regulatory T cells (Tregs) to the autoimmune milieu to traffic, proliferate, and exert suppressive functions. The genetically modified-T cells with artificial receptors are a promising option to suppress autoimmune manifestation and autoinflammatory events. Interestingly, CAR-T cells are modified to a new chimeric auto-antibody receptor T (CAAR-T) cell. This cell, with its specific-antigen, recognizes and binds to the target autoantibodies expressing autoreactive cells and, subsequently, destroy them. Preclinical studies of CAR-T cells demonstrated satisfactory outcomes against autoimmune diseases. However, the lack of target autoantigens remains one of the pivotal problems in the field of CAR-T cells. CAR-based therapy has to pass several hurdles, including stability, durability, trafficking, safety, effectiveness, manufacturing, and persistence, to enter clinical use. The primary goal of this review was to shed light on CAR-T immunotherapy, CAAR-T cell therapy, and CAR-Treg cell therapy in patients with immune system diseases.

Item Type: Article
Keywords: immunotherapy autoimmune diseases Tregs cytotoxic T cells CAR-T cells CAAR-Tregs adoptive cell therapy regulatory t-cells growth-factor-beta cancer-immunotherapy targeted therapy lymphocytes mechanisms memory suppression transplantation interleukin-10 Immunology
Divisions: Education Vice-Chancellor Department > Faculty of Nursing and Midwifery > Department of Nursing
Page Range: p. 12
Journal or Publication Title: Frontiers in Immunology
Journal Index: ISI
Volume: 11
Identification Number: https://doi.org/10.3389/fimmu.2020.603237
ISSN: 1664-3224
Depositing User: خانم موهبت شیوخی
URI: http://eprints.larums.ac.ir/id/eprint/305

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