Repository of Research and Investigative Information

Repository of Research and Investigative Information

Larestan University of Medical Sciences

Induced Pluripotent Stem Cells (iPSCs) Provide a Potentially Unlimited T Cell Source for CAR-T Cell Development and Off-the-Shelf Products

(2021) Induced Pluripotent Stem Cells (iPSCs) Provide a Potentially Unlimited T Cell Source for CAR-T Cell Development and Off-the-Shelf Products. Pharmaceutical Research. pp. 931-945. ISSN 0724-8741

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Abstract

Chimeric antigen receptor T (CAR-T) cell therapy has been increasingly conducted for cancer patients in clinical settings. Progress in this therapeutic approach is hampered by the lack of a solid manufacturing process, T lymphocytes, and tumor-specific antigens. T cell source used in CAR-T cell therapy is derived predominantly from the patient's own T lymphocytes, which makes this approach impracticable to patients with progressive diseases and T leukemia. The generation of autologous CAR-T cells is time-consuming due to the lack of readily available T lymphocytes and is not applicable for third-party patients. Pluripotent stem cells, such as human induced pluripotent stem cells (hiPSCs), can provide an unlimited T cell source for CAR-T cell development with the potential of generating off-the-shelf T cell products. T-iPSCs (iPSC-derived T cells) are phenotypically defined, expandable, and as functional as physiological T cells. The combination of iPSC and CAR technologies provides an exciting opportunity to oncology and greatly facilitates cell-based therapy for cancer patients. However, T-iPSCs, in combination with CARs, are at the early stage of development and need further pre-clinical and clinical studies. This review will critically discuss the progress made in iPSC-derived T cells and provides a roadmap for the development of CAR iPSC-derived T cells and off-the-shelf T-iPSCs.

Item Type: Article
Keywords: CAR-T cell iPSC iPSC-derived T cell off-the-shelf stem cells T cell tumor cell cancer regression human fibroblasts surface-markers generation antigen mouse induction therapy donor differentiation Chemistry Pharmacology & Pharmacy
Divisions: Education Vice-Chancellor Department > Faculty of Nursing and Midwifery > Department of Nursing
Page Range: pp. 931-945
Journal or Publication Title: Pharmaceutical Research
Journal Index: ISI
Volume: 38
Number: 6
Identification Number: https://doi.org/10.1007/s11095-021-03067-z
ISSN: 0724-8741
Depositing User: مهندس مهدی شریفی
URI: http://eprints.larums.ac.ir/id/eprint/369

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