Repository of Research and Investigative Information

Repository of Research and Investigative Information

Larestan University of Medical Sciences

Effects of exercise training on immunological factors in kidney transplant recipients; a randomized controlled trial

(2021) Effects of exercise training on immunological factors in kidney transplant recipients; a randomized controlled trial. Research in Sports Medicine. p. 12. ISSN 1543-8627

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Abstract

The purpose of this study was to investigate the effects of a 12 week exercise training on the immune system of kidney transplant recipients. 23 kidney transplant recipients were randomly divided into two groups including control (n = 10) and training (n =13) groups. The training groups participated in the training for 10 weeks (three days a week each day 60-90 minutes). The control group performed no regular exercise during this time. The blood samples were taken before and after 12 weeks. ELISA and Real-time PCR were used to evaluate cytokine profiles , including TNF-a, IL-6, IL-4, IL-31 and IL-35 as well as T-bet, GATA-3, RORYt and FOXP3, respectively. Finally, the data were analysed , using paired T-test. ELISA results showed decreased levels of TNF-a, increase levels of IL-6 and no significant differences in the IL-35, IL-31, and IL-4 levels in the training group comparison to control group. Gene expression profiles showed significantly increased expression of T-bet and no changes in the GATA-3, RORYt and FOXP3 levels. According to these results, a moderate exercise including aerobic and resistance training could inhibit inflammatory cytokines and have beneficial effects on the immune system, buy this issue needs further research.

Item Type: Article
Keywords: Exercise training immunological factors renal transplantation Sport Sciences
Divisions: Education Vice-Chancellor Department > Faculty of Nursing and Midwifery > Department of Nursing
Page Range: p. 12
Journal or Publication Title: Research in Sports Medicine
Journal Index: ISI
Identification Number: https://doi.org/10.1080/15438627.2021.1906671
ISSN: 1543-8627
Depositing User: مهندس مهدی شریفی
URI: http://eprints.larums.ac.ir/id/eprint/374

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