Repository of Research and Investigative Information

Repository of Research and Investigative Information

Larestan University of Medical Sciences

Circulating levels of adropin and overweight/obesity: a systematic review and meta-analysis of observational studies

(2022) Circulating levels of adropin and overweight/obesity: a systematic review and meta-analysis of observational studies. Hormones-International Journal of Endocrinology and Metabolism. pp. 15-22. ISSN 1109-3099

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Abstract

The association between circulating adropin levels and overweight/obesity is currently unclear. The aim of this study was thus to investigate and seek to determine the association between circulating adropin levels and overweight/obesity using the meta-analysis approach of observational studies. A comprehensive literature search was carried out through the PubMed, Web of Science, and SCOPUS databases to identify relevant observational studies that assessed the relationship between circulating adropin levels and overweight/obesity up to September 2020. A random-effects model was used to compute the pooled weighted mean difference (WMD) with 95 confidence intervals (CI). The meta-analysis of five studies (n = 643 participants) showed that circulating adropin levels were significantly lower in the overweight/obese vs. the normal-weight participants (WMD = - 0.96 ng/ml, 95 CI = - 1.72 to - 0.19, P = 0.01; I-2 = 88.4). In subgroup analyses, lower circulating adropin levels in obese participants compared with normal-weight were observed in Asians (WMD = - 1.58 ng/ml, 95 CI = - 1.96 to - 1.21, P < 0.001; I-2 = 0.00), and in patients with metabolic disorders (WMD = - 1.26 ng/ml, 95 CI = - 1.76 to - 0.77, P < 0.001; I-2 = 44.6), respectively. Circulating adropin levels were significantly lower in overweight/obese vs. normal-weight participants, suggesting a possible role of this hormone in the development of obesity. However, the present research indicates that further studies are needed to conclusively confirm whether adropin is a viable marker of obesity.

Item Type: Article
Keywords: Adropin Obesity Meta-analysis Overweight Observational studies protein-coupled receptor plasma adropin obesity inflammation expression cancer cells gpr19 Endocrinology & Metabolism
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Nutrition
Page Range: pp. 15-22
Journal or Publication Title: Hormones-International Journal of Endocrinology and Metabolism
Journal Index: ISI
Volume: 21
Number: 1
Identification Number: https://doi.org/10.1007/s42000-021-00331-0
ISSN: 1109-3099
Depositing User: مهندس مهدی شریفی
URI: http://eprints.larums.ac.ir/id/eprint/422

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